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Significant favourable differences in three biomarkers of potential harm linked to the development of cardiovascular diseases (11-dTX B2, COHb and sICAM-1) Lower levels of biomarkers of potential harm (WBC and 8-epi-PGF2α) for general inflammation and oxidative stress and Favourable differences in a biomarker of potential harm (HDL) relevant to CVD Favourable differences in a biomarker of potential harm (FeNO) relevant to lung health About this study This clinical study of participating Vuse consumers, smokers, former smokers and never smokers provides comprehensive analysis of 17 biomarkers of exposure (BoE) to priority cigarette smoke toxicants, biomarkers of potential harm (BoH) and physiological measures relevant to cardiovascular conditions, respiratory diseases and cancer